From The Royal Institution.

In the second lecture of the series, Sir Phillips investigates the power of the enzymes.

Watch all the lectures in this series here: https://youtube.com/playlist?list=PLbnrZHfNEDZwJzRXCqVQbUwmocA5Mefzh&si=2ayVkEMTngvAPmcy
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This was recorded on 2 Dec 1980.

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This year marks 200 years of the Royal Institution Christmas Lectures — a world famous series showcasing science, curiosity, and mind-blowing demos, and started by the legendary Michael Faraday himself.

To celebrate, we’re unlocking the archive. Every Saturday, we’ll upload a classic lecture to our YouTube channel — some not seen since they aired on TV. Sign up as a Science Supporter and get early access here:
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From the 1980 programme notes:
Nearly all of the chemical reactions that take place within a living organism are under the control of protein molecules. These protein molecules are known as enzymes and they act as catalysts, controlling the rate at which the chemical reactions take place without being changed themselves. In general, each individual chemical reaction, which might be concerned, for example, with breaking down food molecules into smaller pieces, is controlled by a separate enzyme.

Enzymes and the molecules whose reactions they control have complementary shapes and fit together like jigsaw puzzle pieces. In order to understand how enzymes work, it is essential, therefore, to know their shapes. We shall see how X-rays can be used to study the three-dimensional structures of protein molecules in crystals and how these methods were used at the Royal Institution to work out the structure of an enzyme molecule for the first time. The enzyme was lysozyme from egg-white, which has the ability to kill bacteria, and the studies also showed how it works.

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About the 1980 CHRISTMAS LECTURES
Which came first, the chicken or the egg? This is one of the best known of all riddles without an answer but it is now giving place to a new riddle about the molecules from which chickens and eggs – and human beings – are made. These molecules are proteins and nucleic acids.

This series of six lectures, five presented by David Phillips and one with Max Perutz, showcases the complexity and importance of the proteins that make up so much of life. The lectures weave through the DNA helix, unravelling the mechanism that links DNA and protein production, and asking ‘which came first, the DNA or the protein?’

Find out more about the CHRISTMAS LECTURES here: https://www.rigb.org/christmas-lectures

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