From World Science Festival.
Nobel laureate David Baker joins Brian Greene to discuss groundbreaking work that leverages the chemistry of life to design powerful new molecules with wide ranging applications.
Moderator: Brian Greene
Guest: David Baker
00:00:07 – Introduction: David Baker and Protein Design
00:01:28 – How David Baker Shifted from Philosophy to Biology
00:04:58 – What Are Proteins and How Do They Function?
00:08:26 – How Many Proteins Exist and Have Been Studied?
00:11:33 – Why Protein Folding Is Crucial to Function
00:13:10 – How Scientists Predict Protein Structure
00:18:36- DeepMind’s AlphaFold Breakthrough
00:25:25 – From Prediction to Design: Custom Proteins
00:27:53 – Making Proteins in the Lab: The Process
00:31:06 – Real-World Uses: Influenza & Snake Venom Blockers
00:33:04 – Generative AI for Protein Design
00:35:47 – Building Catalysts to Break Down Plastics & Methane
00:40:42 – Applications in Pharma and Disease
00:45:47 – Making Plants More Climate Resilient
00:51:38 – Future of Protein-Based Machines
00:54:20 – Neurodegenerative Disease Research
00:59:23 – Brain-Computer Interfaces and Sensors
01:01:48 – Adapting to Deep Learning: A Scientist’s Mindset
01:06:17 – Where AI and Physics Methods Intersect
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