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Between 1485 and 1551, England was hit by at least five epidemics of sweating sickness. But after that, the disease supposedly vanished off the face of the Earth. With fatality rates as high as 90% according to some sources (perhaps closer to 30–50% on average), and death often coming in less than a day, it was far more serious than its name might suggest. And scientists still aren’t sure what caused it.

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Sources: https://docs.google.com/document/d/e/2PACX-1vRlkgxD_W6Pjq1RPDjrQIAyRlRgNZgv2jYW9tZNWDxgM31CajyQlMkQoGitQfQjgcriO7HEvNMYTNJq/pub